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Pharmacodynamic Principles - I
In this lecture ´´Pharmacodynamic and Pharmacokinetic Principles´´ is explained. Section one is about ´´Pharmacodynamic Principles - I´´. After introducing pharmacodynamic principles, educator moved to types of drug-receptor interactions. These are agonist drugs and antagonist drugs. Then discussion continues over agonists that inhibit their binding molecules.
Pharmacodynamic Principles - II
Section two is about ‘’Pharmacodynamic Principles – I’’. Educator covers most part of this section in the explanation of agonists, partial agonists, and inverse agonists. After that duration of drug action is discussed. Finally, receptors and inert binding sites are covered.
Pharmacokinetic Principles - I
Section three is about ‘’Pharmacokinetic Principles – I’’. Introduction to pharmacokinetic principles is given. Then information about permeation is delivered. Drug permeation proceeds by several mechanisms. So, educator also explains the mechanisms of drug permeation.
Pharmacokinetic Principles - II
Section four is about ‘’Pharmacokinetic Principles – II’’. Educator gives the illustration of aqueous diffusion. Aqueous diffusion occurs within the larger aqueous compartments of the body. This is followed by lipid diffusion. Lipid diffusion is the most important limiting factor for drug permeation. Special carriers are then discussed. Endocytosis and exocytosis are explained to conclude.
Pharmacokinetic Principles - III
Section five is about ‘’Pharmacokinetic Principles – III’’. This section is started by the explanation of Fick’s Law of Diffusion. Then the discussion continues on Henderson-Hasselbalch Equation. According to Henderson-Hasselbalch Equation, protonated form of a weak acid is the neutral, more lipid-soluble form and unprotonated form of a weak base is the neutral form.